6-Fluoro-3, 4-dihydro-2H-benzopyran-2-carboxylic acid, also known as Fluorocitrate, is an organic compound. Specific properties and uses are as follows:
Nature:
-Chemical formula: C6H5FO4
-Molecular weight: 166.1g/mol
-Appearance: White crystalline solid
-Melting point: 141-143°C
-Solubility: Soluble in water and some organic solvents
-It is a derivative of a tricarboxylic acid, one of which is connected to a carboxylic acid group and also contains a fluorine atom.
Use:
-The main application of Fluorocitrate is to be used as an inhibitor of energy enzymes in biochemical research, especially for certain cyclases and lactate dehydrogenases.
-It can also be used as a tool for studying nervous system diseases, metabolic disorders and energy metabolism.
Preparation Method:
There are many ways to prepare Fluorocitrate. One common method is to prepare by reacting oxalic acid. The specific steps are as follows:
1. Add oxalic acid and trifluoromethanesulfonic acid (or trichloromethanesulfonic acid) to the reaction vessel.
2. The mixture is heated to allow the reaction to proceed.
3. After the reaction is completed, after crystallization and purification, 6-fluoro-3, 4-dihydro-2H-benzopyran-2-carboxylic acid is obtained.
Safety Information:
Fluorocitrate is an organic compound. Pay attention to the following safety precautions during handling:
-Avoid inhaling powder or dust, and maintain a well-ventilated working environment.
-avoid and skin, eyes or mucous membrane contact, such as contact should immediately rinse with plenty of water.
-Wear appropriate protective gloves, goggles and protective clothing during use.
-store should be sealed, away from heat and fire sources, avoid oxidation, sun exposure and high temperature.